AKÜ Araştırma ve Akademik Performans Sistemi
DSpace@AKÜ, Afyon Kocatepe Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü: Öğe , Investigation of the prevalence of irresponsible antibiotic use in large ruminants(Afyon Kocatepe Üniversitesi, 03.10.2025) Tüfekçi, Emre; Ural, Mert Okan; Karaahmetoğlu, Mehmet; Şahin, Orhan GaziBu çalışmada Kayseri ilindeki büyük ruminantlarda akılcı olmayan antibiyotik kullanımının yaygınlığının araştırılması amaçlandı. Bu amaçla Erciyes Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı Ruminant Kliniği’ne teşhis ve tedavi amacıyla hayvanını getiren, daha önce antibiyotik tedavisi uygulamış 120 hayvan sahibine yüz-yüze anket çalışması yapıldı. Çalışmada, veteriner hekim tarafından muayene sonrası reçete edilen antibiyotik uygulamasına devam eden bilinçli hayvan sahipleri (Grup 1, n=23), veteriner hekim tarafından muayene edilmeden, verilen anemnez sonucu veteriner hekim tavsiyesi ile antibiyotik uygulaması yapan hayvan sahipleri (Grup 2, n=56) ve daha önceki uygulamalardan artan ve elinde bulunan antibiyotikleri rastgele seçerek uygulayan hayvan sahipleri (Grup 3, n=41) olarak gruplar oluşturuldu. Veteriner hekimlerin en çok kullandığı (%26,8) ve tavsiye ettiği (%37,0) antibiyotik grubunun beta laktam grubu olduğu tespit edildi. Benzer şekilde hayvan sahiplerinin de en çok kullandığı antibiyotik grubu beta laktam grubu antibiyotiklerdi (%30,8). Antibiyotik kullanılan hayvanlara farklı antibiyotik gruplarının tek veya kombine olarak uygulandığı tespit edildi. Tek bir antibiyotik kullanımının en çok veteriner hekim tarafından uyguladığı (%52,17) ve tavsiye edildiği (%60,71), ikili kombine antibiyotik kullanımının ise en çok Grup 3’teki katılımcılar tarafından uygulandığı görüldü (%48,78). İkiden daha fazla kombine antibiyotik kullanımının ise veteriner hekim tarafından uygulandığı (%21,74) belirlendi. Bu çalışma ile belirli bir ölçekte yaygın ve kontrol dışı antibiyotik kullanımı ortaya konuldu. Sonuç olarak gelecekte ortaya çıkması muhtemel bir gıda krizine karşı hayvansal üretimi korumak ve insan, hayvan ve çevre sağlığını olumsuz etkileyecek bilinçsiz antibiyotik kullanımı sonucu ortaya çıkabilecek dirençli suşlara karşı önlem almak, Veteriner hekimlerin ve yetiştiricilerin akılcı antibiyotik kullanımı hakkında bilgilendirmek, ulusal ve uluslararası boyutta önem arz etmektedir.Öğe Türü: Öğe , The effect of thyme oil and thymol on hepatic gene expression levels in rabbits with ınduced hepatic lipidosis(Afyon Kocatepe Üniversitesi, 03.10.2025) Ekinci, Gencay; Güneş, VehbiRabbits fed a high cholesterol diet (HCD) exhibit various physiopathologic features of hepatic lipidosis. The aim of this study was to investigate the effects of thyme oil and thymol on inflammation-related hepatic gene expression levels in a HCD-induced hepatic lipidosis model. Male New Zealand rabbits were divided into 6 groups. These groups were; Standard rabbit chow, Standard rabbit chow + thymol, Standard rabbit chow + thyme oil, High cholesterol diet, High cholesterol diet + thymol, High cholesterol diet + thyme oil. Blood samples were collected at 0, 4, 8 and 11 weeks during the study. Total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglyceride levels were analyzed. The mRNA expression levels of inflammation-related genes from liver tissue were analyzed by real-time polymerase chain reaction method. The expression levels of interleukin-4 (IL-4), IL-17 and interferon gamma genes were lower, whereas the expression levels of IL-9, IL-13, IL-18 and RAR-related orphan receptor gamma genes were higher in rabbits fed with HCD compared to the normal diet group (p<0.05). Thymol increased T-box transcription factor, IL-4, IL-17 and IL-18 gene expression. Thyme oil increased GATA binding protein 3 and IL-18 gene expression. In conclusion, thymol and thyme oil suppressed the expression of some inflammation-related genes and upregulated the expression of others. It can be stated that thymol and thyme oil may have positive effects on the prevention or correction of the inflammatory process from the gene level in the hepatic lipidosis model induced by HCD.Öğe Türü: Öğe , Detection of the presence of leptospirosis in horses by Elisa method(Afyon Kocatepe Üniversitesi, 03.10.2025) Karataş Yeni, Derya; Arslan, Duygu; Balevi, Aslı; Paksoy, YavuzkanLeptospirosis is one of the common zoonotic diseases worldwide. It significantly affects humans and animals, causing socio-economic losses. Equine leptospirosis often manifests itself with recurrent genital tract infections, reproductive disorders, abortion, embryonic death, and birth of weak foals. Studies on Leptospirosis, especially in horses, are quite limited. For this reason, our study was planned to investigate the transmission cycle in terms of farm animals and public health, and also to determine the presence of Leptospirosis in horses. For our research, 187 horse blood serum samples were collected from different settlements in Turkey. In the collected samples, Leptospira spp. ELISA test was used to investigate the presence of antibodies. A total of 8 samples (4.27%) were detected as seropositive in horse serum samples. The agent, a significant pathogen for both human and animal health, was identified as seropositive. In addition, the high rate of transmission of leptospirosis through contact with infected horses and the potential for spread through different animals should be taken into consideration. Leptospirosis was determined as seropositivity by ELISA in the horses sampled. Therefore, it is important to diagnose and control the infection rapidly.Öğe Türü: Öğe , Effect of chemical castration using high osmolarity solutions on spermatological parameters in rats(Afyon Kocatepe Üniversitesi, 03.10.2025) Şeyma Özer Kaya; İbrahim Canpolat; Hasan Akın [Please purchase a license if using PhraIn study, the changes in spermatological parameters in rats subjected to chemical castration with high osmolarity solutions were investigated. In study, 8 male rats were used in each group. No chemicals were applied to rats in control group. Rats in second group were sterilized surgically. 0.9% physiological saline was administered to 3rd group, 0.9% physiological saline and 10% calcium chloride to 4th group, 20% mannitol to 5th group, 20% mannitol and 10% calcium chloride to 6th group, 20% dextrose to 7th group, 20% dextrose and 10% calcium chloride solutions were administered intratesticularly to 8th group at dose of 0.1 ml/100gr. Andrological findings compared to control group; it was determined that there was a significant difference in sperm motility and sperm density (p<0.001) in groups 3, 5, 7. However, it was observed that there was no difference in rate of abnormal spermatozoon. In groups 2, 4, 6, 8, motility, density, abnormal sperm count and epididymis weights could not be measured because sperm cells could not be collected. In addition, it was determined that the weights of epididymis and right cauda epididymis in groups 3, 5, 7 decreased compared to control (p<0.05), while in groups 2, 4, 6, 8, measurements could not be made because tissue samples could not be taken, and weights of testicles, vesicle seminalis and prostate decreased significantly (p<0.001) compared to control. In conclusion; it has been concluded that giving high osmolarity solutions in combination with calcium chloride will be much more effective in intratesticular chemical sterilization process.Öğe Türü: Öğe , Explainable machine learning framework for milk quality grading(Afyon Kocatepe Üniversitesi, 03.10.2025) Çetintav, Bekir; Yalçın, AhmetThis study introduces an explainable machine learning framework for milk quality grading, combining high predictive performance with transparency and practicality. Utilizing Random Forest and HistGradientBoost models, alongside interpretability techniques like Permutation Feature Importance and LIME, the framework achieves robust classification while providing actionable insights. Global explanations identify pH and Temperature as critical factors, highlighting their significance in real-time monitoring and microbial control. Local explanations, based on the two presented examples, demonstrate the practical utility of individual predictions, offering targeted interventions such as optimizing storage conditions or addressing contamination risks. By bridging the gap between predictive accuracy and interpretability, this framework not only enhances trust and usability for stakeholders but also establishes a new perspective for integrating AI-driven quality control systems into the dairy industry.
