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dc.contributor.authorALİHOSSEİNİ, Hadi; ÇOLAKOĞLU, Ekrem Çağatay; HAYDARDEDEOĞLU, Ali Evren; KURTDEDE, Arif
dc.date.accessioned2019-02-05T08:06:38Z
dc.date.available2019-02-05T08:06:38Z
dc.date.issued2018
dc.identifier.citationBrown DL, Winkle TV, Cecere T, Rushton S, Brachelente C, Cullen JM. Congenital hepatic fibrosis in 5 Dogs. Vet Pathol. 2010; 47: 102-107. Desmet V. What is congenital hepatic fibrosis? Histopathol. 1998; 20: 465–477. Center SA. Chronic liver disease: Current concepts of disease mechanisms. JSAP. 1999; 40: 106‐114. Eulenberg VM, Lidbury JA. Hepatic fibrosis in dogs. J Vet Intern Med. 2018: 32; 26-41. Favier RP. Idiopathic hepatitis and cirrhosis in dogs. Vet Clin North Am: Smal An Pract. 2009: 39; 481-488. Friedman S L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 2000: 275(4); 2247-2250. James FE, Knowles GW, Mansfield CS, Robertson ID. Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. AVJ, 2008; 86: 180-186. Owczarczak S. Chronic Hepatic Fibrosis in an 8 year old French Bulldog. Seminar Paper, Cornell University College of Veterinary Medicine, USA, 2010. Rutger HC, Haywood S, Kelly DF. Idiopathic hepatic fibrosis in 15 dogs. Vet Record. 1993; 133; 115-118. Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagnostic Invest. 2000; 12: 101–110.en_US
dc.identifier.urihttp://dergipark.gov.tr/download/article-file/546723
dc.identifier.urihttp://hdl.handle.net/11630/5345
dc.descriptionIdiopathic hepatic fibrosis (İHF) is an inevitable result of chronic liver disease progressing to cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or juvenile form in German Shepherd Dogs. However, few data have been published on the incidence and prevalence of IHF in canine species. The case report presented here describes idiopathic hepatic fibrosis in four neutered German Shephered dogs with a familial relationship. The main clinical complaints were refractory ascites, variable appetite and progressive weight loss. Hepatic fibrosis was confirmed with diagnostic applications and liver biopsy. Nevertheless, all dogs died in spite of supportive and aggressive treatment. Necropsy was performed in the dogs according to written owner consent. In conclusion, the cases presented here reflect the congenital condition of idiopathic hepatic fibrosis in young German Shepherd Dogs with histopathological evidence. However, there was evidence of familial relationship in the cases presented here.en_US
dc.description.abstractİdiyopatik hepatik fibroz (İHF) siroza kadar gidebilen kronik karaciğer hastalığının kaçınılmaz bir sonucudur. İdiyopatik hepatik fibroz, Alman Çoban Köpeklerinde jüvenil ya da doğmasal olarak şekillenebilmektedir. Bununla birlikte, köpeklerde İHF’nin prevalans veya insidansı hakkında az sayıda veri bulunmaktadır. Sunulan olgu serisi, ailesel ilişkisi bulunan dört Alman Çoban Köpeğindeki idiyopatik hepatik fibrozu tanımlamaktadır. Olgulardaki esas klinik şikayetler; tekrarlayan asites, değişken iştah durumu ve ilerleyici kilo kaybıydı. Hepatik fibroz tanısı diyagnostik uygulamalar ve karaciğer biyopsisi ile doğrulandı. Destekleyici agresif tedaviye ragmen tüm köpekler kaybedildi. Hasta sahibinin izni ile köpeklerde nekropsi gerçekleştirildi. Sonuç olarak, sunulan olgular Alman Çoban Köpeklerinde histopatolojik kanıtı olan konjenital idiyopatik hepatik fibrozu yansıtmaktadır. Bununla birlikte, sunulan olgularda ailesel ilişki kanıtı da söz konusudur.en_US
dc.language.isoengen_US
dc.relation.isversionof10.30607/kvj.453321en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFibroz, idiyopatik, karaciğer, köpek, geneticen_US
dc.titleDört Alman Çoban Köpeğinde Hepatik Fibroz İdiyopatik, Genetik Yatkınlık ya da Ailesel İlişki mi?en_US
dc.title.alternativeHepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?en_US
dc.typearticleen_US
dc.relation.journalKocatepe Veteriner Dergisien_US
dc.contributor.departmentAfyon Kocatepe Üniversitesien_US
dc.identifier.volume11en_US
dc.identifier.startpage501en_US
dc.identifier.endpage507en_US
dc.identifier.issue4en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Yayınıen_US


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