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Isolated perfused rabbit ear model for the assessment of transdermal drug deliveryIsolated perfused rabbit ear model for the assessment of transdermal drug delivery
(Afyon Kocatepe Üniversitesi, Kocatepe Tıp Dergisi, 2003-01)
Isolated perfused rabbit ear model together with full thickness human skin and PDMS membrane were used to investigate the penetration properties of naproxen and the enhancer activity of capsaicin. The effect of capsaicin ...
Effect of long term use of hair dyes on the DNA damage in healthy female subjectsEffect of long term use of hair dyes on the DNA damage in healthy female subjects
(Afyon Kocatepe Üniversitesi, Kocatepe Tıp Dergisi, 2002-01)
To Date, the toxic effects of hair dyes on DNA have been investigated by several in vivo and in vitro tests and various conflicting results have been reported. To clarify this toxicity, we used "co met assay" which is a ...
Analysis of DNA damage using the comet assay in female patients treated with phenytoin for epilepsy
(Afyon Kocatepe Üniversitesi, Kocatepe Tıp Dergisi, 2001-05)
Women with epilepsy have been encouraged to consider marriage and child bearing in recent years. Antiepileptic drugs are mostly used such as phenytoin, but its effect on fetus health and its long term effects on DNA have ...
The use of bone injection gun in the loading of phenytoin an experimental study in dogs
(Afyon Kocatepe Üniversitesi, Kocatepe Tıp Dergisi, 2001-01)
Status epilepticus can cause irreversible cerebral injury if it prolongs and it is essential to terminate seizure rapidly. Antiepileptic drugs should be introduced to the patients intravenously (IV), but it is almost ...
Intraosseous infusion of diazepam using spinaf needle
(Afyon Kocatepe Üniversitesi, Kocatepe Tıp Dergisi, 2001-05)
Seizure can cause serious brain damage if it prolongs. It is general need to terminate seizure as soon as possible using anticonvulsant drugs via intravenous (IV) route. But, it is very difficult to achieve secure IV line ...