AKÜ Araştırma ve Akademik Performans Sistemi
DSpace@AKÜ, Afyon Kocatepe Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü: Öğe , Identification and distribution of helminth species in cattle from çorum province(Afyon Kocatepe Üniversitesi, 01.03.2026) Madak, Elif; Gönenç, BahadırHelminths are among the most prevalent parasitic infections affecting cattle worldwide, leading to substantial economic losses and, in severe cases, mortality. This study was carried out between January and June 2025 in Çorum Province, Türkiye, to assess the prevalence and distribution of helminth infections in cattle. Fecal samples were collected from 410 cattle representing different breeds, sexes, and age groups across 13 villages. Samples were examined macroscopically and analyzed using the Fülleborn flotation, Benedek sedimentation, and Baermann-Wetzel techniques to detect helminth eggs and larvae. Among the 410 cattle examined, 143 (34.9%) were found to be infected with one or more helminth species, with Trichostrongylidae being the most prevalent: 88 (21.46%), followed by Paramphistomum spp., 52 (12.68%), Moniezia spp., 14 (3.41%), Trichuris spp., 11 (2.68%), Dicrocoelium spp., 8 (1.95%), Toxocara vitulorum, 3 (0.73%), Fasciola spp., 1 (0.24%), and Nematodirus spp., 1 (0.24%). In cattle infected with Trichostrongylidae, egg counts were generally low (≤100 eggs per gram of feces, EPG). Statistical analysis revealed significant differences in infection rates among age groups, with the highest prevalence observed in cattle between one and two years of age (p < 0.001). Additionally, males exhibited significantly higher infection rates than females (p = 0.034).Öğe Türü: Öğe , The protective effect of coenzyme q10 on serum anti-müllerian hormone levels in rats treated with cyclophosphamide(Afyon Kocatepe Üniversitesi, 01.03.2026) Yıldız, MehmetAnti-Müllerian hormone (AMH) is widely used in veterinary medicine to assess reproductive health. Cyclophosphamide (CP) is a chemotherapeutic and immunosuppressive drug that has been reported to reduce AMH levels and cause damage to ovarian reserves, although findings vary depending on study design. Coenzyme Q10 (CoQ10), known for its antioxidant properties, has been suggested to have a protective role against oxidative stress-related ovarian damage. This study was conducted to examine how CP affects serum AMH levels in rats and whether CoQ10 supplementation could help reduce any negative impact. A total of 35 Wistar Albino rats were used in the study. They were divided into five groups: control, sham, CP, CoQ10, and CP+CoQ10. All substances were administered by oral gavage. CP was dissolved in distilled water and administered at a dose of 6 mg/kg/day, while CoQ10 was dissolved in olive oil and given at a dose of 2.8 mg/kg/day. The treatments lasted for four weeks. Results showed that CP alone did not significantly change AMH levels (p>0.05). In contrast, CoQ10 alone led to a significant increase in serum AMH levels (p<0.05). However, when CP and CoQ10 were given together, no significant difference in AMH levels was observed. This may suggest that CP interferes with or masks the effect of CoQ10 on the ovaries. These findings may contribute to a better understanding of the interaction between CP and CoQ10, especially in terms of dosage, duration and timing of treatment, in future studies.Öğe Türü: Öğe , Morin reduces ciprofloxacin-ınduced brain damage by regulating oxidative stress, ınflammation, and histopathological changes(Afyon Kocatepe Üniversitesi, 01.03.2026) Aygörmez, Serpil; Akaras, Nurhan; Dalkılınç, Elif; Maraşlı, ŞabanCiprofloxacin (CPFX), one of the fluoroquinones, is an antibacterial antibiotic that is used in the treatment of urinary tract, respiratory, abdominal and gastrointestinal infections as well as having negative side effects on the central nervous system. Morin, a bioactive flavonoid, is an antioxidant with neuroprotective properties thanks to its many pharmacological properties. The protective effect off Morin against brain damage caused by CPFX, broad spectrum antibiotic, was investigated. Twentyeight female rats were divided into four groups as control, Morin, CPFX, CPFX+Morin. CPFX, Morin was administered once a day for seven days. Oxidative stress and inflammation parameters were analyzed to determine brain tissue damage and histopathological analysis was performed to determine tissue damage and structural changes. According to the findings obtained as a result of the analyses, CPFX increased nuclear factor kappa B (NF-B), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin 1β (IL-1β) and decreased glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) in brain. Co-administration of CPFX with Morin increased GSH and GPx, SOD, CAT and decreased NF-B, MDA, TNF-α, IL-1β levels. According to findings, when evaluated together, it was found that CPFX caused damage in brain tissue by causing oxidative stress and inflammation and Morin as a supportive treatment reduced the damage in brain tissue by bringing these markers closer to normal.Öğe Türü: Öğe , Antrodia cinnamomea reduces oxidative ınjury and protects cardiac histology in doxorubicin-ınduced cardiotoxicity(Afyon Kocatepe Üniversitesi, 01.03.2026) Yakut, Seda; Özkanlar, SeçkinDoxorubicin (DOX) cardiotoxicity is induced by oxidative stress and results in myocardial damage. We assessed the efficacy of Antrodia cinnamomea in alleviating DOX-induced cardiac injury in rats. Twenty-four male Sprague-Dawley rats were randomly assigned to one of four groups: Control, DOX (2 mg/kg i.p., every other day for 10 days), Antrodia cinnamomea (100 mg/kg p.o., daily), or DOX + Antrodia cinnamomea (2 mg/kg i.p., every other day for 10 days and 100 mg/kg p.o., daily). H&E was used to look at the hearts and give them a semi-quantitative injury score. We investigated malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) in left-ventricular homogenates. DOX caused a lot of damage to the heart muscle, disorganized myofibrils, created vacuoles in the cytoplasm, changed the shape of the nucleus, and caused interstitial edema. The injury scores were much higher than in the Control group (p <0.05). Biochemically, DOX elevated MDA levels while reducing SOD and GSH levels (p <0.05). Antrodia cinnamomea alone was similar to Control. Co-treatment (DOX + Antrodia cinnamomea) significantly reduced MDA and partially restored SOD and GSH in comparison to DOX (all p <0.05), which was consistent with lower histopathology scores; however, the values did not fully revert to Control levels. Antrodia cinnamomea lessens the cardiotoxicity caused by DOX by improving redox balance and protecting the structure of the heart muscle. These results support Antrodia cinnamomea as a potential adjunct to alleviate anthracycline cardiotoxicity and affirm the need for mechanistic and translational studies incorporating apoptosis/inflammation markers, ultrastructural validation, and pharmacokinetic profiling.Öğe Türü: Öğe , Evaluation of in vitro rumen degradability of fermented, dried, and pelleted tomato greenhouse pruning residues in buffaloes and cows(Afyon Kocatepe Üniversitesi, 01.03.2026) Karatosun, Sümeyra; Özçınar, ÜmitIn this study, the in vitro rumen degradability characteristics of tomato greenhouse pruning residues were evaluated in buffalo and cattle. The feasibility of using tomato pruning waste, which arises from increased greenhouse production, as an alternative roughage source in animal feed has been investigated. Thus, the aim is to prevent both economic losses and contribute to environmental sustainability. In the study, tomato greenhouse pruning waste was subjected to chemical analysis, and the dry matter (DM; 91.68%), crude protein (CP; 15.60%), crude ash (CA; 17.80%), crude fat (CF; 3.77%), and neutral detergent fibre (NDF; 48.22%) contents were determined. Additionally, the ruminal digestibility characteristics of the material were determined using the Ankom DaisyII in vitro incubation system. In in vitro digestibility tests using rumen fluids from buffalo and cattle, digestibility parameters were compared. The results obtained showed that tomato greenhouse pruning residues have a high dry matter content and suitable fibre content, while the levels of crude protein and crude fat are evaluable. According to the in vitro digestibility results, buffalo were found to digest crude protein and crude fat more efficiently than cows, respectively, which was statistically significant (31.58%; 25.25%; p<0.01, 23.41%; 14.33%; p<0.05). In conclusion, tomato greenhouse pruning waste has the potential to be used as an alternative roughage source in ruminant feeding. Especially in buffalo, incorporating these wastes into feed programs can reduce feed costs and contribute to the utilisation of agricultural waste
