AKÜ Araştırma ve Akademik Performans Sistemi
DSpace@AKÜ, Afyon Kocatepe Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü: Öğe , Sequence conservation and variability in canine distemper virus proteins(Afyon Kocatepe Üniversitesi, 24.12.2025) Temizkan, Seçil Sevinç; Temizkan, Mehmet CevatCanine distemper virus (CDV), a member of the Paramyxoviridae family, is a highly contagious pathogen with a broad host range, causing considerable morbidity and mortality in domestic and wild carnivores. In this study, a total of 2882 complete and partial CDV sequences, deposited in GenBank until 17 August 2025, were analysed. The sequences were aligned and categorized according to their genes (N, P, C, M, F, H, and L), and consensus sequences were generated. Comparative analyses revealed that the M protein was the most conserved (73.35%), followed by the L protein (69.58%). H (2.15%) and N (2.10%) proteins displayed the lowest levels of conservation. The highest variability was observed in the F (3.32%) and H (0.82%) proteins. Critical residues of the H protein, previously associated with viral tropism and antigenicity, were evaluated: position 238 was predominantly Y, position 241 was G, and position 530 was G. Furthermore, the residue at position 519 of the N protein, reported to be linked with virulence, was identified as R in the consensus sequence. Structural modelling of the H protein was performed, highlighting the spatial localization of these key residues. The results underline the genetic diversity and evolutionary dynamics of CDV and provide insights into antigenic drift, host adaptation, and viral persistence. These findings are expected to support future studies focusing on epitope mapping, vaccine development, and antiviral drug design.Öğe Türü: Öğe , Functional anatomy of the carpal region in sprague dawley strain rats(Afyon Kocatepe Üniversitesi, 24.12.2025) Üstündağ,Yasemin; Koçak, Ümit; Giousemoglou, Belkin; Aydemir, Muhammed Ali; Yakar, Ahmet BeraDating back to 1830, Rattus norvegicus holds the distinction of being one of the first mammals domesticated for use in scientific researches. While detailed anatomical information about the human carpal region is available, such information is lacking for rats. The current study aims to resolve the ambiguity in the literature by determining which bones constitute the carpal bones of Sprague Dawley starin rats ,the number and arrangement of these bones. Additionally, the study seeks to elucidate how the carpal tunnel, which is important in translational anatomy, is formed and which structures pass through it.In the study, seven 9-month-old female Sprague Dawley strain rats carpal regions were examined, macroscobically, morphometrically and radiologically.The carpal bones of Sprague Dawley rats were examined and found to be arranged in two rows: proximal and distal. A total of six carpal bones were identified, two in the proximal row and four in the distal row. The formation of the carpal tunnel in rats has been observed as follows. It is noted to form between the distal end of the antebrachium and the distal carpal bones. Compared to human and rat carpal bones and carpal tunnel, both of the structures are quite different each other.Therefore, it has been concluded that these rats are unsuitable for experimental surgical models, especially those focusing on the carpal region.Öğe Türü: Öğe , Morphological and histological investigation of the effects of garlic extract on the intestine of goldfish (carassius auratus auratus)(Afyon Kocatepe Üniversitesi, 24.12.2025) Duman, Muhammed; Mazı, Ali; Abdulkadir Oflaz; Çağdaş Kara; Güler, Sabire; Onguncan, Onur; Ajmi, Nihed; Taşçı, GörkemGarlic (Allium sativum) has been widely recognized for its therapeutic properties and potential use as a feed additive in aquaculture. This study aimed to investigate the morphological and histological effects of garlic extract on the intestinal health and growth performance of goldfish (Carassius auratus auratus). Goldfish were fed diets supplemented with 5 and 10 mg/g of garlic extract for three months. Results indicated significant improvements in both weight gain and intestinal villus length, particularly in the 10 mg/g group, compared to the control group. The control group showed a decline of 21% in the overall metric between the two sampling periods, with intermediate percentage increases during the individual sampling intervals. In contrast, the groups receiving garlic supplementation demonstrated significant increases. The 5 mg/g garlic group exhibited a 37% total increase, while the 10 mg/g garlic group showed the highest overall increase of 53%. These findings suggest that garlic extract can enhance digestive efficiency and overall growth in goldfish, presenting a promising natural alternative for growth promoters in ornamental fish species. Further research is recommended to explore its long-term effects and efficacy across different fish species.Öğe Türü: Öğe , Selected serum biochemical parameters and acute phase protein levels in sheep with acute ruminal lactic acidosis(Afyon Kocatepe Üniversitesi, 24.12.2025) Baydar, Ersoy; Bozukluhan, Kadir; Merhan, Oğuz; Kaya, Feyyaz; Kırbaş, AkınThis study examined changes in acute phase protein (APP) levels and biochemical parameters in sheep with acute ruminal lactic acidosis (ARLA). The study population consisted of 20 Akkaraman sheep diagnosed with ARLA and 10 healthy sheep of the same breed, which served as the control group. All sheep were aged 1–2 years. Ruminal fluid samples were collected from both groups using a stomach tube and analyzed immediately. Blood samples were also taken from the jugular veins of all animals. Compared to the control group, sheep with ARLA exhibited significantly increased levels of haptoglobin (Hp) (p<0.001), ceruloplasmin (Cp) (p<0.05), aspartate aminotransferase (AST) (p<0.001), alkaline phosphatase (ALP) (p<0.001), blood urea nitrogen (BUN) (p<0.001), and creatinine (Crea) (p<0.001). In contrast, levels of albumin (Alb) (p<0.05), total protein (TP) (p<0.05), and iron (Fe) (p<0.05) were significantly lower in sheep with ARLA. In conclusion, ARLA induces notable changes in APP concentrations and biochemical parameters in sheep, which may play a role in the pathogenesis and diagnosis of the disease.Öğe Türü: Öğe , Histopathological investigation of liver, kidney and heart tissues in paclitaxel treated Mice(Afyon Kocatepe Üniversitesi, 24.12.2025) Korkmaz, Oya; Küçükgünay, Sadık; Öztürk, Ali Erdem; Tozak Yıldız, Halime; Bucak, Mustafa NumanPaclitaxel (PTS) is a widely used chemotherapy drug for various types of cancer, but it often causes significant toxicity in multiple organ systems. The aim of this study was to investigate the deleterious effects of PTS on liver, kidney and heart in an experimental animal model. Male Balb/c mice aged 8-10 weeks were included in the study. Mice were divided into two groups as control (n:5) and PTS (n:5). On the 1st, 3rd and 5th days, saline was administered intraperitoneally to control group mice and 2 mg/kg PTS to PTS group mice. Animals were sacrificed on day 7 and liver, kidney and heart tissues were collected and histopathological examinations (Hematoxylin Eosin and Masson Trichrome staining) were performed. While the liver tissue of the control group showed a normal histological appearance, marked damage such as apoptotic cell increase, congestion, sinusoidal dilatation, epithelial vacuolisation, central vein dilatation and mononuclear cell infiltration were observed in the PTS group (p<0.001). In the PTS group, atrophy of tubules and renal corpuscles, loss of brushy edge, tubular dilatation, interstitial oedema and vascular congestion were observed (p<0.001). Myocardial necrosis, abnormal arrangement of fibres, oedema and increased mononuclear cell infiltration were observed in cardiac tissue in the PTS group. Our findings indicate that PTS has a damaging potential on liver, kidney and heart.
